Zofran and Morning Sickness

It is estimated that about 75% of pregnant women will experience some degree of “morning sickness.” Half of all expectant mothers will have both nausea and vomiting and the other 25% will have only nausea.

The most severe cases of nausea and vomiting in pregnancy (NVP) are called hyperemesis gravidarium (meaning “excessive vomiting during pregnancy”). Fortunately, these cases are rare, occurring in only about 1% of pregnancies, and even more rarely (one in 500), may require hospitalization if acidosis, dehydration or other systemic effects are present.

For most women, taking a multivitamin starting early in pregnancy may decrease nausea and vomiting. Treatment of NVP with ginger has also been suggested as a nonpharmacologic option.

The American College of Obstretricians and Gynelcologists (ACOG) states that with respect to more severe symptoms, vitamin B6 may be suggested first, and doxylamine, an antihistamine medication found in over-the-counter sleep aids, may be added if vitamin B6 alone does not relieve the symptoms.

ACOG, in a brochure answering common questions about morning sickness, also states “drugs that combat nausea and vomiting may be prescribed” but does not specify any particular drug. In a 2004 practice bulletin, ACOG does refer to certain classes of drugs such as antihistamine receptor blockers, phenothiazines, and benzamides as being safe and efficacious to take for more severe cases of morning sickness during pregnancy.

It is noteworthy that ACOG in its 2004 bulletin did not include Zofran (ondansetron) as a recommended medication for morning sickness—for severe cases or otherwise. Zofran has now been linked in several studies to an increased risk of birth defects (principally cleft palate, cleft lip, and cardiac malformations) when taken during the first trimester of pregnancy.


    Attorney Tor and the whole team at Spangenberg Shibley & Liber, including the receptionist, made me feel welcome, comforted, and confident throughout my case. They showed me respect and kindness from start to finish.

    - Zandra S.

    I was feeling uncertain but after I met with Nick I felt at ease & confident. Communication was great, I was constantly informed and everyone was genuine & compassionate.

    - Sonja S.

    Coming in, we were unsure if we had a case. After meeting with Peter Brodhead, we were very confident with him. I was always comfortable because everyone was professional and friendly.

    - Elaine B.

    I liked the professionalism, efficiency, and thoroughness of your team efforts. I would like Sheila Schebek recognized for her knowledge of account details as quickly as I presented questions. She provided confidence and security in all matters.

    - John S.

    Before I called you, I felt awful & depressed when I heard about cancer. After I called you and discussed, I felt better knowing that this law firm cared for me. They were very kind and well communicated with me.

    - Gary S.

Put Award-Winning
Trial Lawyers On Your Side

Contact Our Team for a Free & Confidential Case Evaluation
  • Please enter your first name.
  • Please enter your last name.
  • Please enter your phone number.
    This isn't a valid phone number.
  • Please enter your email address.
    This isn't a valid email address.
  • Please make a selection.
  • Please enter a message.