SILICONE OIL PARTICLES CONTAMINATE EYE INJECTIONS IN OFF-LABEL USE OF AVASTIN IN TREATMENT OF MACULAR DEGENERATION
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Avastin (bevacizumab), which has FDA approval for intravenous treatment colorectal, certain lung, breast, brain, and kidney cancers, has for several years now been used by ophthalmologists in eye injections for the treatment of wet age-related macular degeneration (AMD). Avastin eye injections have been shown to be an effective treatment for AMD. But these eye injections are an off-label use of the drug, meaning that the FDA has not approved it for this particular use.
Genentech, the maker of Avastin, does not manufacture or supply prefilled syringes with Avastin. Rather, it is compounding pharmacies—some of them quite large with a multistate distribution network—who purchase vials of Avastin and prefill the syringes with the drug and ship them frozen or refrigerated to the ophthalmologists.
Unfortunately, many of the compounding pharmacies have been using plastic syringes (usually diabetic syringes) that are coated with silicone and which were not designed or approved for injection into the eye. When silicone freezes, it becomes a solid.
The unfortunate result of these actions by the compounding pharmacies is that many patients are getting Avastin contaminated with silicone particles injected into their eyes. Some of these silicone particles are being injected into the eye as solids. Whether solids or as silicone microdroplets, these contaminated injections can cause further vision problems for patients who are already suffering from a serious and progressive eye condition.
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Decisions made regarding drugs are not always done on behalf of the patient. The facilities repackaging medication should be held accountable for their carelessness. If you’re experiencing vision problems after getting treatment for AMD, see your doctor about the source of your drug and the container in which it was sitting. Talk to one of our unsafe drugs & products attorneys about your situation. We’ve been winning lawsuits since 1946.
Contact us at (216) 600-0114 or fill out our online form to discuss your case. We operate on a contingency fee basis, so we don’t get paid unless you do.
- Preventing Silicone Oil Contamination of the Eye with Avastin Injections, Part I
- The Problems of Silicone Oil Contamination with Avastin (Bevacizumab) Eye Injections
- How Silicone Particles Get in Your Eye from Avastin (Bevacizumab) Injections
- Why are Avastin Eye Injections Contaminated with Silicone?
- Avastin Eye Injections Could Cause Silicone "Floaters" in Eye